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Proceedings Paper

Multifractal modeling, segmentation, prediction, and statistical validation of posterior fossa tumors
Author(s): Atiq Islam; Khan M. Iftekharuddin; Robert J. Ogg; Fred H. Laningham; Bhuvaneswari Sivakumar
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Paper Abstract

In this paper, we characterize the tumor texture in pediatric brain magnetic resonance images (MRIs) and exploit these features for automatic segmentation of posterior fossa (PF) tumors. We focus on PF tumor because of the prevalence of such tumor in pediatric patients. Due to varying appearance in MRI, we propose to model the tumor texture with a multi-fractal process, such as a multi-fractional Brownian motion (mBm). In mBm, the time-varying Holder exponent provides flexibility in modeling irregular tumor texture. We develop a detailed mathematical framework for mBm in two-dimension and propose a novel algorithm to estimate the multi-fractal structure of tissue texture in brain MRI based on wavelet coefficients. This wavelet based multi-fractal feature along with MR image intensity and a regular fractal feature obtained using our existing piecewise-triangular-prism-surface-area (PTPSA) method, are fused in segmenting PF tumor and non-tumor regions in brain T1, T2, and FLAIR MR images respectively. We also demonstrate a non-patient-specific automated tumor prediction scheme based on these image features. We experimentally show the tumor discriminating power of our novel multi-fractal texture along with intensity and fractal features in automated tumor segmentation and statistical prediction. To evaluate the performance of our tumor prediction scheme, we obtain ROCs and demonstrate how sharply the curves reach the specificity of 1.0 sacrificing minimal sensitivity. Experimental results show the effectiveness of our proposed techniques in automatic detection of PF tumors in pediatric MRIs.

Paper Details

Date Published: 27 March 2008
PDF: 12 pages
Proc. SPIE 6915, Medical Imaging 2008: Computer-Aided Diagnosis, 69153C (27 March 2008); doi: 10.1117/12.770902
Show Author Affiliations
Atiq Islam, Univ. of Memphis (United States)
Khan M. Iftekharuddin, Univ. of Memphis (United States)
Robert J. Ogg, St. Jude Children's Research Hospital (United States)
Fred H. Laningham, St. Jude Children's Research Hospital (United States)
Bhuvaneswari Sivakumar, Univ. of Memphis (United States)

Published in SPIE Proceedings Vol. 6915:
Medical Imaging 2008: Computer-Aided Diagnosis
Maryellen L. Giger; Nico Karssemeijer, Editor(s)

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