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Proceedings Paper

MR-guided catheter-based excitation emission optical spectroscopy for in vivo tissue characterization
Author(s): D. A. Herzka; M. S. Kotys; S. Krueger; B. J. Traughber; J. Heroux; A. M. Gharib; J. Ohayon; S. Weiss; R. I. Pettigrew; B. J. Wood
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Paper Abstract

Excitation emission spectroscopy (EES) has been used in the past to characterize many different types of tissue. This technique uses multiple excitation wavelengths and samples a complete optical spectrum for each, yielding an excitation-emission matrix (EEM). Upon study of the EEM, it is possible to determine the presence of multiple optical contrast agents since these dyes can have characteristic spectra that can be separated. Here, we demonstrate EES specifically designed for use in conjunction with MR. This EES is applied with an in-suite control setup that permits real-time navigation, utilizing active MR tracking catheters, and providing a platform for MR-guided tissue characterization. The EES system is used in a demonstration experiment to highlight MR imaging, MR guidance in conjunction with a catheter-based optical measurement.

Paper Details

Date Published: 20 March 2008
PDF: 7 pages
Proc. SPIE 6918, Medical Imaging 2008: Visualization, Image-Guided Procedures, and Modeling, 69181U (20 March 2008); doi: 10.1117/12.770758
Show Author Affiliations
D. A. Herzka, Philips Research North America (United States)
National Institutes of Health (United States)
M. S. Kotys, National Institutes of Health (United States)
S. Krueger, Philips Research Europe (Germany)
B. J. Traughber, National Institutes of Health (United States)
J. Heroux, National Institutes of Health (United States)
A. M. Gharib, National Institutes of Health (United States)
J. Ohayon, National Institutes of Health (United States)
Lab. TIMC-IMAG, DynaCell, Institut de l'Ingénierie et del'Information de Santé (France)
S. Weiss, Philips Research Europe (Germany)
R. I. Pettigrew, National Institutes of Health (United States)
B. J. Wood, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 6918:
Medical Imaging 2008: Visualization, Image-Guided Procedures, and Modeling
Michael I. Miga; Kevin Robert Cleary, Editor(s)

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