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Proceedings Paper

Estimating MR relaxation in a single shot: considerations for estimation accuracy
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Paper Abstract

Quantitative and spatially accurate maps of local NMR relaxation rates from single-shot acquisitions are of value for functional MRI and dynamic contrast studies. Addressing this need is SS-PARSE (Single-shot parameter assessment by recovery from signal encoding), a recently introduced MRI technique for mapping magnetization magnitude and phase, frequency, and net transverse decay rate R2* from a single-shot (<70 msec) signal. Instead of implicitly modeling the local signal as arising from a constant magnetization vector, SS-PARSE models the evolution in phase and the decay in amplitude of the local signal and estimates the local parameter maps producing the observed signal. Because the local signal model used is fundamentally more accurate than the model implicitly used in most current MRI methodology, SS-PARSE maps are inherently free from geometric errors due to off-resonance frequencies. The accuracy of the parameter estimates is determined by (a) the information available in the signal (the form of the local signal model, the sampling pattern, and random noise), and by (b) the effectiveness of the estimation algorithm in extracting the information present in the signal. Sources of bias and random errors are discussed. The performance of the method is investigated using experimental phantom data.

Paper Details

Date Published: 12 March 2008
PDF: 10 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69160W (12 March 2008); doi: 10.1117/12.770505
Show Author Affiliations
Donald B. Twieg, Univ. of Alabama at Birmingham (United States)
Stanley J. Reeves, Auburn Univ. (United States)


Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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