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Proceedings Paper

Nonrigid registration of carotid ultrasound and MR images using a "twisting and bending" model
Author(s): Nuwan D. Nanayakkara; Bernard Chiu; Abbas Samani; J. David Spence; Grace Parraga; Jagath Samarabandu; Aaron Fenster
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Paper Abstract

Atherosclerosis at the carotid bifurcation resulting in cerebral emboli is a major cause of ischemic stroke. Most strokes associated with carotid atherosclerosis can be prevented by lifestyle/dietary changes and pharmacological treatments if identified early by monitoring carotid plaque changes. Plaque composition information from magnetic resonance (MR) carotid images and dynamic characteristics information from 3D ultrasound (US) are necessary for developing and validating US imaging tools to identify vulnerable carotid plaques. Combining these images requires nonrigid registration to correct the non-linear miss-alignments caused by relative twisting and bending in the neck due to different head positions during the two image acquisitions sessions. The high degree of freedom and large number of parameters associated with existing nonrigid image registration methods causes several problems including unnatural plaque morphology alteration, computational complexity, and low reliability. Our approach was to model the normal movement of the neck using a "twisting and bending model" with only six parameters for nonrigid registration. We evaluated our registration technique using intra-subject in-vivo 3D US and 3D MR carotid images acquired on the same day. We calculated the Mean Registration Error (MRE) between the segmented vessel surfaces in the target image and the registered image using a distance-based error metric after applying our "twisting bending model" based nonrigid registration algorithm. We achieved an average registration error of 1.33±0.41mm using our nonrigid registration technique. Visual inspection of segmented vessel surfaces also showed a substantial improvement of alignment with our non-rigid registration technique.

Paper Details

Date Published: 11 March 2008
PDF: 8 pages
Proc. SPIE 6914, Medical Imaging 2008: Image Processing, 691411 (11 March 2008); doi: 10.1117/12.770337
Show Author Affiliations
Nuwan D. Nanayakkara, Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Bernard Chiu, Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Abbas Samani, The Univ. of Western Ontario (Canada)
J. David Spence, Robarts Research Institute (Canada)
Grace Parraga, Robarts Research Institute (Canada)
Jagath Samarabandu, The Univ. of Western Ontario (Canada)
Aaron Fenster, Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 6914:
Medical Imaging 2008: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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