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Proceedings Paper

Optimization of beam parameters and iodine quantification in dual-energy contrast enhanced digital breast tomosynthesis
Author(s): Sylvie Puong; Xavier Bouchevreau; Nicolas Duchateau; Razvan Iordache; Serge Muller
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Paper Abstract

Dual-Energy Contrast Enhanced Digital Breast Tomosynthesis (DE CEDBT) is a promising technique for breast cancer detection, which combines the strengths of functional and 3D imaging. In the present study, we first focused on the optimization of the acquisition parameters for the low and high-energy projections, which leads to a trade-off between image quality in the recombined slices and the Average Glandular Dose (AGD) delivered to the patient. Optimized parameters were found and experimentally validated on phantom images. Then, we addressed the problem of iodine quantification in the recombined slices. In DE CEDBT, iodine quantification is limited by the z-resolution, due to the restricted angle acquisition inherent to tomosynthesis. We evaluated the lesion thickness above which determination of iodine volumetric concentration is possible. For lesions below this thickness, estimation of iodine concentration is possible if a priori information or a model on the shape of the lesion is available. Iodine quantification for lesions located near the breast boundary is also challenging, due to scatter border effects and variation of the breast thickness in this region. A scatter correction algorithm based on a deconvolution scheme and a thickness compensation algorithm were applied on the low and high-energy projections. Corrected images showed a more accurate quantification of iodine.

Paper Details

Date Published: 18 March 2008
PDF: 11 pages
Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69130Z (18 March 2008); doi: 10.1117/12.770148
Show Author Affiliations
Sylvie Puong, GE Healthcare (France)
Univ. Paris XI (France)
Xavier Bouchevreau, GE Healthcare (France)
Nicolas Duchateau, Institut d'Optique (France)
Razvan Iordache, GE Healthcare (France)
Serge Muller, GE Healthcare (France)

Published in SPIE Proceedings Vol. 6913:
Medical Imaging 2008: Physics of Medical Imaging
Jiang Hsieh; Ehsan Samei, Editor(s)

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