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Proceedings Paper

Comparison of laterality index of upper and lower limb movement using brain activated fMRI
Author(s): Mohammad Hossein Harirchian; Mohammad Ali Oghabian; Alireza Rezvanizadeh; Niousha Bolandzadeh
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Paper Abstract

Asymmetry of bilateral cerebral function, i.e. laterality, is an important phenomenon in many brain actions such as motor functions. This asymmetry maybe altered in some clinical conditions such as Multiple Sclerosis (MS). The aim of this study was to delineate the laterality differences for upper and lower limbs in healthy subjects to compare this pattern with subjects suffering from MS in advance. Hence 9 Male healthy subjects underwent fMRI assessment, while they were asked to move their limbs in a predetermined pattern. The results showed that hands movement activates the brain with a significant lateralization in pre-motor cortex in comparison with lower limb. Also, dominant hands activate brain more lateralized than the non-dominant hand. In addition, Left basal ganglia were observed to be activated regardless of the hand used, While, These patterns of Brain activation was not detected in lower limbs. We hypothesize that this difference might be attributed to this point that hand is usually responsible for precise and fine voluntary movements, whereas lower limb joints are mainly responsible for locomotion, a function integrating voluntary and automatic bilateral movements.

Paper Details

Date Published: 20 March 2008
PDF: 13 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69161Q (20 March 2008); doi: 10.1117/12.769776
Show Author Affiliations
Mohammad Hossein Harirchian, Imam Khomeini Hospital (Iran)
Mohammad Ali Oghabian, Tehran Univ. (Iran)
Alireza Rezvanizadeh, Tehran Univ. (Iran)
Niousha Bolandzadeh, Tehran Univ. (Iran)

Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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