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Proceedings Paper

Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): evaluation with time-density curve angiographic analysis and histology
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Paper Abstract

In this study, we compare the results obtained from Time-Density Curve (TDC) analysis of angiographic imaging sequences with histological evaluation for a rabbit aneurysm model treated with standard stents and new asymmetric vascular stents (AVS) placed by image-guided endovascular deployment. AVSs are stents having a low-porosity patch region designed to cover the aneurysm neck and occlude blood flow inside. To evaluate the AVSs, rabbits with elastase-induced aneurysm models (n=20) were divided into three groups: the first (n=10) was treated with an AVS, the second (n=5) with a non-patch standard coronary stent, and third was untreated as a control (n=5). We used TDC analysis to measure how much contrast media entered the aneurysm before and after treatment. TDCs track contrast-media-density changes as a function of time over the region of interest in x-ray DSA cine-sequences. After 28 days, the animals were sacrificed and the explanted specimens were histologically evaluated. The first group showed an average reduction of contrast flow into the aneurysm of 95% after treatment with an AVS with fully developed thrombus at 28 days follow-up. The rabbits treated with standard stents showed an increase in TDC residency time after treatment and partial-thrombogenesis. The untreated control aneurysms displayed no reduction in flow and were still patent at follow-up. The quantitative TDC analysis findings were confirmed by histological evaluation suggesting that the new AVS has great potential as a definitive treatment for cerebro-vascular aneurysms and that angiographic TDC analysis can provide in-vivo verification.

Paper Details

Date Published: 20 March 2008
PDF: 12 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69160P (20 March 2008); doi: 10.1117/12.769504
Show Author Affiliations
A. Dohatcu, Toshiba Stroke Research Ctr. (United States)
SUNY, Univ. at Buffalo (United States)
C. N. Ionita, Toshiba Stroke Research Ctr. (United States)
SUNY, Univ. at Buffalo (United States)
A. Paciorek, SUNY, Univ. at Buffalo (United States)
D. R. Bednarek, Toshiba Stroke Research Ctr. (United States)
SUNY, Univ. at Buffalo (United States)
K. R. Hoffmann, Toshiba Stroke Research Ctr. (United States)
SUNY, Univ. at Buffalo (United States)
S. Rudin, Toshiba Stroke Research Ctr. (United States)
SUNY, Univ. at Buffalo (United States)


Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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