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Proceedings Paper

Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy
Author(s): Jianhua Zhao; Zhiwei Huang; Haishan Zeng; David I. McLean; Harvey Lui
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Paper Abstract

Raman spectroscopy is a non-invasive optical technique that is very sensitive to the structure and conformation of biochemical constitutes. It has been successfully used to study dysplasia and cancer in a variety of human tissues including skin. Researchers have a strong interest in quantitative analysis of the Raman spectra in the hope to find the quantitative molecule changes associated with cancers. Because skin is the largest organ in humans, it is very important to study the variability of Raman spectra for different body sites. In this presentation we report our quantitative analysis of normal skin Raman spectra of twenty-five body sites. Partial least square (PLS) analysis was used to quantify the skin molecules from the in vivo Raman spectra. We find that the absolute Raman intensity differs from person to person and from body site to body site. However the normalized Raman spectra are identical for the same body site. It is particularly interesting to find that the distribution of skin molecules is clustered for the same body regions.

Paper Details

Date Published: 8 February 2008
PDF: 7 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684209 (8 February 2008); doi: 10.1117/12.769373
Show Author Affiliations
Jianhua Zhao, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
British Columbia Cancer Research Ctr. (Canada)
Zhiwei Huang, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
British Columbia Cancer Research Ctr. (Canada)
Haishan Zeng, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
British Columbia Cancer Research Ctr. (Canada)
David I. McLean, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
British Columbia Cancer Research Ctr. (Canada)
Harvey Lui, Univ. of British Columbia (Canada)
Vancouver Coastal Health Research Institute (Canada)
British Columbia Cancer Research Ctr. (Canada)


Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory; Guillermo J. Tearney; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Brian Jet-Fei Wong; Justus F. R. Ilgner; Henry Hirschberg; Steen J. Madsen, Editor(s)

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