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Proceedings Paper

Investigation of photoacoustic guidance of diffusive optical tomography
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Paper Abstract

We report the first experimental investigations of photoacoustic guidance of diffusive optical tomography for detection and characterization of optical contrast targets. The hybrid system combined an 8-source, 10-detector reflection mode frequency domain DOT imager with either orthogonal and reflection-geometry photoacoustic systems. The PAT subsystems imaged two-dimensional cross-sections to define centers and radii of regions of interest for a dual-zone mesh DOT imaging algorithm. Phantom absorbers, 1 cm in diameter, of high and low contrast, were spaced 1.5 to 2.5 cm apart at depths ranging from 1 to 2 cm in a turbid medium. Without PAT guidance, the absorber DOT images in many cases were merged and indistinguishable. With PAT guidance, the two targets were well resolved and the reconstructed absorption coefficients improved to 86-130% of the true values. In addition, using both pulse-echo and photoacoustic image detection, the photoacoustic guidance correctly distinguished mechanical from optical contrast providing more specific target information and reconstruction accuracy.

Paper Details

Date Published: 28 February 2008
PDF: 10 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560V (28 February 2008); doi: 10.1117/12.769235
Show Author Affiliations
John Gamelin, Univ. of Connecticut (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)


Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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