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Proceedings Paper

Volumetric imaging of microcirculations in human retina and choroids in vivo by optical micro-angiography
Author(s): Lin An; Ruikang K. Wang
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Paper Abstract

A new noninvasive optical angiography, optical micro-angiography (OMAG), is recently developed. Three-dimensional flow image has been performed with Optical Angiography. The bulk motion artifacts caused by the bulk motion movement were eliminated by compensating phase varieties with Doppler shift due to the bulk motion. This method enhanced the quality of flow image greatly and has the capability of resolving three dimensional (3-D) distribution of dynamic blood perfusion at the capillary level within microcirculatory beds in vivo. The imaging contrast of blood perfusion is based on the endogenous light scattering from the moving blood cells biological tissue; thus no exogenous contrasting agents are necessary. In this paper, we presented the application of this method to visualize the 3D vasculature of ocular vessels for in vivo human retinal imaging. Depth-resolved volumetric views of the retina and choroid vasculatures are also obtained by 1) segmenting the retina and choroid layers from the OCT micro-structure images to produce two masks, 2) apply the resulted two masks onto the 3D flow image to result en-face projection views of the blood vessel networks in retina and choroid. We compare the results with those from Doppler OCT and optical coherence angiography, and show that OMAG delivers superior imaging performance.

Paper Details

Date Published: 6 February 2008
PDF: 9 pages
Proc. SPIE 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V, 68550A (6 February 2008); doi: 10.1117/12.769085
Show Author Affiliations
Lin An, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)

Published in SPIE Proceedings Vol. 6855:
Complex Dynamics and Fluctuations in Biomedical Photonics V
Valery V. Tuchin; Lihong V. Wang, Editor(s)

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