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Proceedings Paper

Measurement of microfluidic flow velocity profile with two Doppler optical coherence tomography systems
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Paper Abstract

Doppler Optical Coherence Tomography (DOCT) is a useful technique for flow measurements. Its potential applications include industrial suspension viscosity measurements and blood flow measurements. In this work, a flow velocity profile of 1% Intralipid was measured in a capillary with an inner diameter of 0.8 mm and in a microfluidic channel with a cross-section of 1000 μmx100 μm. Two different DOCT measurement systems were utilized in the experiments: a commercial conventional OCT system and a laboratory-built DOCT system, intended particularly for flow velocity measurements. In the laboratory-built DOCT system, depth scanning was achieved by moving the whole measurement system with the reference mirror fixed. This modification from a conventional OCT system improves lateral resolution during the scanning process. A syringe pump was used to induce flow in the capillary. Flow velocity was measured with flow rates from 1 ml/min to 3.33 ml/min using both measurement systems. For a flow rate of 3.33 ml/min, both systems gave reasonable results. For flow rates lower than 3.33 ml/min, however, the laboratory-built DOCT system gave much better results. Its mean measurement error was as low as 0.8%, while that of the commercial OCT was 6.8%. Measured with the laboratory-built DOCT system, capillary force-induced flow velocity in the microfluidic channel was around 2 mm/s. The commercial OCT system, on the other hand, proved unsuitable for flow measurements in the microfluidic channel due to its high scanning speed.

Paper Details

Date Published: 22 February 2008
PDF: 8 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630F (22 February 2008); doi: 10.1117/12.768500
Show Author Affiliations
Janne Lauri, Univ. of Oulu (Finland)
Meng Wang, Univ. of Oulu (Finland)
Matti Kinnunen, Univ. of Oulu (Finland)
Risto Myllylä, Univ. of Oulu (Finland)

Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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