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Proceedings Paper

Phantoms for polarized light exhibiting controllable scattering, birefringence, and optical activity
Author(s): Michael F. G. Wood; Nirmalya Ghosh; Xinxin Guo; I. Alex Vitkin
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Paper Abstract

Recently, the use of polarized light for medical diagnosis and therapeutic management has seen increased interest due the noninvasive nature of light-tissue interactions. Examples of the use of polarized light include polarization imaging to enhance spatial resolution in turbid media, selective imaging of polarized light to increase surface contrast in tissue, polarization-sensitive optical coherence tomography (PS-OCT), and glucose monitoring. With these emerging applications there is a need for controllable phantoms to validate the emerging techniques; however, this has been done only to a limited degree primarily due to the difficulty in creating controllable phantoms. The primary effects of tissue on the polarization of light are scattering, linear birefringence, and optical activity (circular birefringence). An ideal phantom would exhibit all these effects simultaneously in a controllable fashion. We have achieved this through the use of polyacrylamide gels with polystyrene microspheres added as scattering particles, strain applied to the gels to create birefringence, and sucrose added for optical activity. The phantom methodology has been validated using our polarimetry system. Currently, the phantom system is being used to extend our work in birefringence mapping of the myocardium and to further our work in characterizing tissue.

Paper Details

Date Published: 21 February 2008
PDF: 10 pages
Proc. SPIE 6870, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue, 68700F (21 February 2008); doi: 10.1117/12.767679
Show Author Affiliations
Michael F. G. Wood, Ontario Cancer Institute, Univ. Health Network and Univ. of Toronto (Canada)
Nirmalya Ghosh, Ontario Cancer Institute, Univ. Health Network and Univ. of Toronto (Canada)
Xinxin Guo, Ontario Cancer Institute, Univ. Health Network and Univ. of Toronto (Canada)
I. Alex Vitkin, Ontario Cancer Institute, Univ. Health Network and Univ. of Toronto (Canada)


Published in SPIE Proceedings Vol. 6870:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue
Robert J. Nordstrom, Editor(s)

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