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Proceedings Paper

Dynamic of gold nanoparticles labeling studied on the basis of OCT and backscattering spectra of tissues and phantoms
Author(s): G. G. Akchurin; I. L. Maksimova; V. P. Rybukho; V. V. Lychagov; B. N. Khlebtsov; N. G. Khlebtsov; G. G. Akchurin; I. O. Kolbenev; V. Yu. Maksimov; O. G. Naumova; A. A. Skaptsov; G. S. Terentyuk; V. V. Tuchin
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Paper Abstract

A new interference scheme of low-coherent interferometry was considered. This interference system does not use a special supporting beam. An object is lighted up by optical field directly from source of light. Back-scattered radiation is put to correlation analysis using Michelson scanning interferometer. Such unsupported interference system has a number of advantages, e.g. conducting experiments in vivo. A comparison of spatial sensitivity of OCT and HRT tomographs resolution was made during identification of local inhomogeneity in presence of nanoshells and nanorods in bio-phantoms and bio-tissues. Plasmon-resonant gold nanoparticles can be used as a new class of contrast agents in OCT diagnostics. The theoretical part of our study was to simulate the backscattering signal related to the process of electromagnetic wave propagation through a system of discrete scattering particles with consideration the effects of different scattering multiplicity. By using the computer Monte Carlo simulations, we calculated the spectra of collimated transmission, diffuse forward and back scattering for the systems of gold spherical particles and shells.

Paper Details

Date Published: 6 February 2008
PDF: 10 pages
Proc. SPIE 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V, 68550K (6 February 2008); doi: 10.1117/12.767641
Show Author Affiliations
G. G. Akchurin, Saratov State Univ. (Russia)
I. L. Maksimova, Saratov State Univ. (Russia)
V. P. Rybukho, Saratov State Univ. (Russia)
V. V. Lychagov, Saratov State Univ. (Russia)
B. N. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
N. G. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
G. G. Akchurin, Saratov State Univ. (Russia)
I. O. Kolbenev, Saratov State Medical Univ. (Russia)
V. Yu. Maksimov, Saratov State Medical Univ. (Russia)
O. G. Naumova, Ophthalmologic Hospital of Saratov Region (Russia)
A. A. Skaptsov, Saratov State Univ. (Russia)
G. S. Terentyuk, First Banian Hospital of Saratov (Russia)
V. V. Tuchin, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 6855:
Complex Dynamics and Fluctuations in Biomedical Photonics V
Valery V. Tuchin; Lihong V. Wang, Editor(s)

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