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Proceedings Paper

Fourier domain pump-probe optical coherence tomography: hemoglobin imaging at 830 nm
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Paper Abstract

The detailed 3-D mapping of tissue microcirculation, including blood oxygen saturation and flow, would provide important biometrics needed to understand the cause and progression of numerous diseases. To that end we have started developing a two-color Fourier domain Pump-Probe Optical Coherence Tomography (PPOCT) system designed specifically to image hemoglobin with the eventual goal of measuring blood oxygen saturation. This system utilizes a two-color pump-probe scheme chosen to maximize the potential imaging depth by probing in the near IR where the tissue scattering properties are most favorable and pumping in the visible where the hemoglobin light absorption is most efficient. A sample consisting of pure hemoglobin placed between two coverslips has been used for the initial demonstration and to begin the process of optimizing the system.

Paper Details

Date Published: 18 February 2008
PDF: 8 pages
Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 68471A (18 February 2008); doi: 10.1117/12.766839
Show Author Affiliations
Brian E. Applegate, Texas A&M Univ. (United States)
Desmond Jacob, Texas A&M Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 6847:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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