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Proceedings Paper

Influence of gold nanoparticles on platelets functional activity in vitro
Author(s): Garif G. Akchurin; George G. Akchurin; Alexey N. Ivanov; Vyacheslav F. Kirichuk; George S. Terentyuk; Boris N. Khlebtsov; Nikolay G. Khlebtsov
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Paper Abstract

Now in the leading biomedical centers of the world approved new technology of laser photothermal destruction of cancer cells using plasmon gold nanoparticles. Investigations of influence of gold nanoparticles on white rat platelets aggregative activity in vitro have been made. Platelet aggregation was investigated in platelet rich plasma (PRP) with help of laser analyzer 230 LA <<BIOLA>> (Russia). Aggregation inductor was ADP solution in terminal concentration 2.5 micromole (<<Reanal>>, Russia). Gold nanoshells soluted in salt solution were used for experiments. Samples of PRP were incubated with 50 or 100 μl gold nanoshells solution in 5 minute, after that we made definition ADP induced platelet aggregation. We found out increase platelet function activity after incubation with nanoparticles solution which shown in maximum ADP-induced aggregation degree increase. Increase platelet function activity during intravenous nanoshells injection can be cause of thrombosis on patients. That's why before clinical application of cancer cell destruction based on laser photothermal used with plasmon gold nanoparticles careful investigations of thrombosis process and detail analyze of physiological blood parameters are very necessary.

Paper Details

Date Published: 21 February 2008
PDF: 6 pages
Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690V (21 February 2008); doi: 10.1117/12.765076
Show Author Affiliations
Garif G. Akchurin, Saratov State Univ. (Russia)
George G. Akchurin, Saratov State Univ. (Russia)
Alexey N. Ivanov, Saratov State Medical Univ. (Russia)
Vyacheslav F. Kirichuk, Saratov State Medical Univ. (Russia)
George S. Terentyuk, First Veterinary Clinic (Russia)
Boris N. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Nikolay G. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)

Published in SPIE Proceedings Vol. 6869:
Plasmonics in Biology and Medicine V
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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