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Proceedings Paper

Detection of abnormalities in biological tissue using optical coherence tomography
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Paper Abstract

We studied the performance of an OCT imaging modality on the task of detecting an abnormality in biological tissue. Optical propagation in biological samples is dominated by scattering due to fluctuations in refractive index. We used the first order multiple scattering approximation to describe the scattered field from the tissue. The biological tissue was described by it permittivity field and the corresponding scattering potential. The normal state of the tissue (the background) was modeled as a spatial Poisson field of randomly distributed scattering centers, and the abnormality (the target) as a region with a higher concentration of scattering centers embedded in the background. The target detectability was then calculated using a quadratic observer. We considered the effect of fluctuations from the broadband source, the shot noise fluctuation of the imaging system, and the scattering noise due to refractive index fluctuation in the biological tissue. We also studied the detectability of an embedded abnormality in biological tissue with respect to to size of th abnormality.

Paper Details

Date Published: 12 February 2008
PDF: 12 pages
Proc. SPIE 6849, Design and Quality for Biomedical Technologies, 68490L (12 February 2008); doi: 10.1117/12.764735
Show Author Affiliations
K. Cheong, College of Optical Sciences, Univ. of Arizona (United States)
E. Clarkson, College of Optical Sciences, Univ. of Arizona (United States)
J. P. Rolland, College of Optics and Photonics, Univ. of Central Florida (United States)

Published in SPIE Proceedings Vol. 6849:
Design and Quality for Biomedical Technologies
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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