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Proceedings Paper

Toward single-molecule detection with very compact DNA sequencer based on single-photon avalanche diode array
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Paper Abstract

The development of a very-compact DNA sequencer instrument based on Single Photon Avalanche Diode (SPAD) for microchip electrophoresis is here reported. The planar epitaxial SPAD combines the typical advantages of microelectronic devices with high sensitivity. We present a miniaturized system based on a custom array of SPAD, purposely designed to be compatible with Amersham Biosciences commercial markers. This system is the first example of very compact, ultra-sensitive, portable and low cost DNA sequencer. It may represent a breakthrough in DNA sequencing system and open the way to the development of a new category of portable low-cost apparatus.

Paper Details

Date Published: 21 February 2008
PDF: 9 pages
Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620D (21 February 2008); doi: 10.1117/12.764508
Show Author Affiliations
Ivan Rech, Politecnico di Milano (Italy)
Stefano Marangoni, Politecnico di Milano (Italy)
Angelo Gulinatti, Politecnico di Milano (Italy)
Massimo Ghioni, Politecnico di Milano (Italy)
MPD Micro-Photon-Devices (Italy)
Sergio Cova, Politecnico di Milano (Italy)
MPD Micro-Photon-Devices (Italy)

Published in SPIE Proceedings Vol. 6862:
Single Molecule Spectroscopy and Imaging
Jörg Enderlein; Zygmunt K. Gryczynski; Rainer Erdmann, Editor(s)

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