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Proceedings Paper

Miniaturized probe using 2 axis MEMS scanner for endoscopic multiphoton excitation microscopy
Author(s): Woonggyu Jung; Shuo Tang; Tiquiang Xie; Daniel T. McCormick; Yeh-Chan Ahn; Jianping Su; Ivan V. Tomov; Tatiana B. Krasieva; Bruce J. Tromberg; Zhongping Chen
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Paper Abstract

The practical limitation of in vivo multiphoton excitation microscopy (MPM) is the lack of a compact and flexible probe. Most MPM depends on the bench-top microscope, which prohibits expansion of in vivo application. In this study, we introduced a miniaturized MPM probe using a microelectromechanical system (MEMS) scanning mirror and a doubleclad photonic crystal fiber (DCPCF). Benefits from both a MEMS mirror and a DCPCF overcome current obstacles for probe development, such as size reduction, rapid scanning, efficient delivery of short pulses, and high collection rate of fluorescent signals. In this study, the completed probe was 1 cm in outer diameter and 14 cm in length. The probe was then integrated to the MPM system and used to image fluorescent beads, paper and biological specimens.

Paper Details

Date Published: 21 February 2008
PDF: 7 pages
Proc. SPIE 6851, Endoscopic Microscopy III, 68510D (21 February 2008); doi: 10.1117/12.764356
Show Author Affiliations
Woonggyu Jung, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Shuo Tang, Univ. of British Columbia (Canada)
Tiquiang Xie, Beckman Laser Institute (United States)
Daniel T. McCormick, Advanced MEMS (United States)
Yeh-Chan Ahn, Beckman Laser Institute (United States)
Jianping Su, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Ivan V. Tomov, Beckman Laser Institute (United States)
Tatiana B. Krasieva, Beckman Laser Institute (United States)
Bruce J. Tromberg, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 6851:
Endoscopic Microscopy III
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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