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Proceedings Paper

Frequency encoded assessment of retinal physiology
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Paper Abstract

We demonstrate in-vivo functional imaging of the human retina with Fourier domain optical coherence tomography employing frequency encoding of an excitation pattern. The principle is based on projecting a modulated rectangular pattern across the foveal region and acquiring a time series of B-Scans at the same vertical position across the pattern. The idea is to modulate the excitation with a frequency that is distinct from the heartbeat and irregular motion artifacts. Fourier analysis of the time series at each transverse position in the B-scan series allows assessing the retinal response as change in the FDOCT reflectivity signal exactly at the pattern modulation frequency. We observe a change in retinal reflectivity within the region of the outer segment photoreceptor layer exactly at the pattern modulation frequency.

Paper Details

Date Published: 25 February 2008
PDF: 6 pages
Proc. SPIE 6844, Ophthalmic Technologies XVIII, 68440I (25 February 2008); doi: 10.1117/12.764330
Show Author Affiliations
Rainer A. Leitgeb, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Medical Univ. of Vienna (Austria)
Roland Michaely, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Adrian Bachmann, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Theo Lassner, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Cedric Blatter, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 6844:
Ophthalmic Technologies XVIII
Bruce E. Stuck; Michael Belkin; Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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