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Proceedings Paper

Fluorescence molecular tomography using a priori photoacoustic data
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Paper Abstract

We present the first hybrid photoacoutic fluorescence molecular tomography system, capable of three-dimensional imaging of both fluorochrome and chromophore distributions in highly scattering and absorbing tissues. Quantitative three-dimensional maps of optical absorption coefficient are acquired using photoacoustic tomography. The reconstructed absorption data is fed into the Fluorescence Molecular Tomography inversion scheme in order to improve its accuracy and quatification capabilities in the presence of strong and distributed absorbers that are expected to bias stand-alone fluorescence reconstructions. At all, having both techniques in one hybrid modality yields a system that combines high molecular specificity and targeting flexibility of fluorescent imaging and high spatial resolution functional information obtained via photo-acoustic images.

Paper Details

Date Published: 11 March 2008
PDF: 9 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685617 (11 March 2008); doi: 10.1117/12.764272
Show Author Affiliations
Daniel Razansky, Massachusetts General Hospital and Harvard Medical School (United States)
Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Vasilis Ntziachristos, Massachusetts General Hospital and Harvard Medical School (United States)
Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)


Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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