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Proceedings Paper

In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice
Author(s): Toshiaki Suzuki; Y. Hattori; Takashi Katagiri; Hiroki Mitsuoka; Atsushi Kanno; Kennichi Satoh; Toru Asakura; Toru Shimosegawa; Hidetoshi Sato
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Paper Abstract

Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo microscope Raman spectroscopy. Comparing the spectra of living pancreatic cancer tissue to that of the dead same tissue, it is found that they are different each other. In the subtraction spectrum, Raman bands observed at 937, 1251, 1447 and 1671 cm-1 are appeared in negative direction and those observed at 966 and 1045 cm-1 are appeared in positive direction. The results strongly suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. The present result demonstrates the importance of in vivo, real time studies of biomedical tissues using Raman spectroscopy.

Paper Details

Date Published: 10 March 2008
PDF: 4 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 685314 (10 March 2008); doi: 10.1117/12.764129
Show Author Affiliations
Toshiaki Suzuki, Optical Biopsy Development Research Unit, RIKEN (Japan)
Y. Hattori, Optical Biopsy Development Research Unit, RIKEN (Japan)
Takashi Katagiri, Optical Biopsy Development Research Unit, RIKEN (Japan)
Hiroki Mitsuoka, Optical Biopsy Development Research Unit, RIKEN (Japan)
Atsushi Kanno, Tohoku Univ. Graduate School of Medicine (Japan)
Kennichi Satoh, Tohoku Univ. Graduate School of Medicine (Japan)
Toru Asakura, Tohoku Univ. Graduate School of Medicine (Japan)
Miyagi Gakuin Women's Univ. (Japan)
Toru Shimosegawa, Tohoku Univ. Graduate School of Medicine (Japan)
Hidetoshi Sato, Optical Biopsy Development Research Unit, RIKEN (Japan)


Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Wolfgang Petrich; Robert R. Alfano; Alvin Katz, Editor(s)

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