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Proceedings Paper

Fluorescence diffuse optical tomography with structural a priori information
Author(s): Yuting Lin; Orhan Nalcioglu; Gultekin Gulsen
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Paper Abstract

Fluorescence diffuse optical tomography (FT) is an emerging molecular imaging technique that can spatially resolve both fluorophore concentration and lifetime parameters. In this study, we investigated the performance of a frequency domain FT system for inclusions with various sizes and contrast levels. Due to the ill-posedness of the FT problem, the fluorescence parameters can not be recovered accurately. The reconstructed fluorescence parameters depend on the signal to background contrast and size of the compartments containing the fluorophores. Recently, imaging with multiple modalities has become a popular trend. Different modalities give different information on the subject under investigation. Here, we evaluated the improvement in FT reconstruction when structural a priori information from a second imaging modality was incorporated. The results demonstrated that the structural a priori information was crucial to be able to recover both parameters with high accuracy. Without such a priori information, the same fluorophore concentration for different object sizes could not be recovered to the same value. On the other hand, when the structural a priori information was available, both fluorescence parameters could be recovered within 15% error for all the cases.

Paper Details

Date Published: 14 February 2008
PDF: 12 pages
Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500Z (14 February 2008); doi: 10.1117/12.764080
Show Author Affiliations
Yuting Lin, Univ. of California/Irvine (United States)
Orhan Nalcioglu, Univ. of California/Irvine (United States)
Gultekin Gulsen, Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 6850:
Multimodal Biomedical Imaging III
Fred S. Azar; Xavier Intes, Editor(s)

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