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Proceedings Paper

Improved representation of retinal data acquired with volumetric Fd-OCT: co-registration, visualization, and reconstruction of a large field of view
Author(s): Robert J. Zawadzki; Alfred R. Fuller; Stacey S. Choi; David F. Wiley; Bernd Hamann; John S. Werner
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Paper Abstract

Advances in Fourier-domain optical coherence tomography (Fd-OCT) permit visualization of three-dimensional morphology of in-vivo retinal structures in a way that promises to revolutionize clinical and experimental imaging of the retina. The relevance of these advances will be further increased by the recent introduction of several commercial Fd-OCT instruments that can be used in clinical practice. However, due to some inherent limitations of current Fd-OCT technology (e.g., lack of spectroscopic information, inability to measure fluorescent signals), it is important to co-register Fd-OCT data with images obtained by other clinical imaging modalities such as fundus cameras and fluorescence angiography to create a more complete interpretation and representation of structures imaged. The co-registration between different imaging platforms becomes even more important if small retinal changes are monitored for early detection and treatment. Despite advances in volume acquisition speed with FD-OCT, eye/head motion artifacts can be still seen on acquired data. Additionally high-sampling density, large field-of-view (FOV) Fd-OCT volumes may also be needed for comparison with conventional imaging. In standard Fd-OCT systems, higher sampling density and larger imaging FOV (with constant sampling densities) lead to longer acquisition time which further increases eye/head motion artifacts. To overcome those problems, we tested 3D stitching of multiple, smaller retinal volumes which can be acquired in a less time (reduction of motion artifacts) and/or when stitched create a larger FOV representation of the retina. Custom visualization software that makes possible manual co-registration and simultaneous visualization of volumetric Fd-OCT data sets is described. Volumetric visualizations of healthy retinas with corresponding fundus pictures are presented followed by examples of retinal volumes of high sampling density that are created from multiple "standard" Fd-OCT volumes.

Paper Details

Date Published: 25 February 2008
PDF: 8 pages
Proc. SPIE 6844, Ophthalmic Technologies XVIII, 68440C (25 February 2008); doi: 10.1117/12.764070
Show Author Affiliations
Robert J. Zawadzki, Univ. of California/Davis (United States)
Alfred R. Fuller, Univ. of California/Davis (United States)
Stacey S. Choi, Univ. of California/Davis (United States)
David F. Wiley, Univ. of California/Davis (United States)
Stratovan Corp. (United States)
Bernd Hamann, Univ. of California/Davis (United States)
Stratovan Corp. (United States)
John S. Werner, Univ. of California/Davis (United States)

Published in SPIE Proceedings Vol. 6844:
Ophthalmic Technologies XVIII
Bruce E. Stuck; Michael Belkin; Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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