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Proceedings Paper

Gold nanoshell mediated hyperthermia enhances the efficacy of radiation therapy
Author(s): Parmeswaran Diagaradjane; Anil Shetty; James Wang; Andrew Elliot; Jon Schwartz; Shujun Shentu; Chul Park; Amit Deorukhkar; Jason Stafford; Sang Cho; James Tunnell; John Hazle; Sunil Krishnan
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Paper Abstract

Despite convincing evidence for hyperthermic radiosensitization, the invasive means of achieving and monitoring hyperthermia and the lack of good thermal dosimetry have hindered its use in routine clinical practice. A non-invasive method to generate and monitor hyperthermia would provide renewed enthusiasm for such treatments. Near-infrared absorbing gold nanoshells have been shown to accumulate preferentially in tumors via the enhanced permeability and retention effect and have been used for thermal ablation of tumors. We evaluated the use of these nanoshells to generate hyperthermia to evaluate the anti-tumor effects of combining gold nanoshell mediated hyperthermia with radiotherapy. Laser settings were optimized for hyperthermia in a mouse xenograft model to achieve a temperature rise of 40- 41°C in the tumor periphery and 37-38°C (ΔT=4-5°C) deeper within the tumors. The ΔT measurements were verified using both thermocouple and magnetic resonance thermal imaging (MRTI) temperature measurements. Tumor re-growth delay was estimated by measuring tumor size after treatment with radiation (10Gy single dose), hyperthermia (15 minutes at 40°C), and hyperthermia followed by radiation and control. Significant difference (p <0.05) in the tumor volume doubling time was observed between the radiation group (13 days) and combination treatment group (25 days). The immunofluorescence staining for the hypoxic, proliferating cells and the vasculature corroborated our hypothesis that the radiosensitization is in part mediated by increased initial perfusion and subsequent collapse of vasculature that leads to acute inflammatory response in the tumor. The increased vascular perfusion immediately after gold nanoshell mediated hyperthermia is confirmed by dynamic contrast enhanced magnetic resonance imaging.

Paper Details

Date Published: 22 February 2008
PDF: 8 pages
Proc. SPIE 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, 68650N (22 February 2008); doi: 10.1117/12.764021
Show Author Affiliations
Parmeswaran Diagaradjane, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Anil Shetty, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
James Wang, Nanospectra Biosciences, Inc. (United States)
Andrew Elliot, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jon Schwartz, Nanospectra Biosciences, Inc. (United States)
Shujun Shentu, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Chul Park, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Amit Deorukhkar, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jason Stafford, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Sang Cho, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
James Tunnell, The Univ. of Texas at Austin (United States)
John Hazle, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Sunil Krishnan, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 6865:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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