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Proceedings Paper

Direct-write patterning of nanostructured sensory waveguides for integrated optical bioimaging applications
Author(s): Mohamad Hajj-Hassan; Timothy Gonzalez; Hagop Djeghelian; Ebrahim Ghafar-Zadeh; Daniel Therriault; Vamsy Chodavarapu; Mark Andrews
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Paper Abstract

We report the development of a novel methodology for patterning of nanostructured sensory materials using multi-dimensional microstructured support platforms for optical bioimaging applications. Specifically, the support platforms are fabricated using direct-write technique and sol-gel derived xerogel thin-films to form the sensor materials. This creates a simple and versatile method for developing complex 3-D microstructures that have the combined capabilities of biochemical sensing, microfluidic sample distribution for sensor arrays, and direct integration with Complimentary Metal-Oxide Semiconductor (CMOS) Integrated Circuits (ICs) used for sensor signal detection and processing. More importantly, this methodology would enable the development of large-scale arrayed sensing platforms for applications in cell-culture analysis and tissue imaging. The configuration and fabrication of the proposed microstructures, which consist of planar ridge and hollow waveguides, will be described in detail. As a prototype implementation, we demonstrate direct-write ridge waveguide support structures coated with luminophore-doped xerogels that are responsive to gaseous oxygen (O2) concentration.

Paper Details

Date Published: 22 February 2008
PDF: 8 pages
Proc. SPIE 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, 686504 (22 February 2008); doi: 10.1117/12.763965
Show Author Affiliations
Mohamad Hajj-Hassan, McGill Univ. (Canada)
Timothy Gonzalez, McGill Univ. (Canada)
Hagop Djeghelian, McGill Univ. (Canada)
Ebrahim Ghafar-Zadeh, McGill Univ. (Canada)
Daniel Therriault, Ecole Polytechnique de Montréal (Canada)
Vamsy Chodavarapu, McGill Univ. (Canada)
Mark Andrews, McGill Univ. (Canada)

Published in SPIE Proceedings Vol. 6865:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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