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Proceedings Paper

Molecular specific photoacoustic imaging with plasmonic nanosensors
Author(s): Srivalleesha Mallidi; Evgeniya Yantsen; Timothy Larson; Konstantin Sokolov; Stanislav Emelianov
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Paper Abstract

Gold nanoparticles functionalized with anti-EGFR antibodies undergo molecular specific aggregation on the cellular membrane and later within the cell that leads to a red shift in the plasmon resonance frequency of the gold nanoparticles. Capitalizing on this effect, we previously demonstrated on tissue phantoms that highly sensitive and selective detection of cancer cells can be achieved using the combination of photoacoustic imaging and molecular specific gold nanoparticles. To further evaluate the efficacy of molecular specific photoacoustic imaging technique in detecting deeply situated tumors, small animal experiments were performed. In this study, two gelatin solutions mixed with cells labeled with gold nanoparticles and cells mixed with polyethylene glycol-thiol (mPEG-SH) coated gold nanoparticles were injected in a mouse abdomen ex-vivo. The photoacoustic and ultrasound images from the same crosssection of the region before and after the injections were obtained using a 25 MHz single element ultrasound transducer interfaced with pulsed laser system. The results of our study suggest that the molecular specific photoacoustic imaging with plasmonic nanosensors could be used to detect deeply embedded tumors.

Paper Details

Date Published: 11 March 2008
PDF: 7 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685616 (11 March 2008); doi: 10.1117/12.763903
Show Author Affiliations
Srivalleesha Mallidi, Univ. of Texas at Austin (United States)
Evgeniya Yantsen, Univ. of Texas at Austin (United States)
Timothy Larson, Univ. of Texas at Austin (United States)
Konstantin Sokolov, Univ. of Texas at Austin (United States)
M.D. Anderson Cancer Ctr. (United States)
Stanislav Emelianov, Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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