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Proceedings Paper

Phenomenology of optical scattering from plasmonic aggregates for application to biological imaging and clinical therapeutics
Author(s): Kort Travis; Jesse Aaron; Nathan Harrison; Konstantin Sokolov
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Paper Abstract

Near-field coupling between plasmonic resonant nanoparticles and the associated shifts in scattering spectra enables the accomplishment of unprecedented observation of the co-localization dynamics of in-situ biomolecules on nanometer length-scales. We have recently shown that resonant nanoparticles conjugated to antibodies for cell-surface receptors provide a sensitive probe allowing the unambiguous resolution of not only the time sequence, but also the details of the intracellular pathway, for receptor-mediated endocytosis in live cells. In terms of general principles, the classical electrodynamics determining the scattering cross-section for nanoparticle aggregates is straightforward. However, the specifics of the angular dependence of the differential cross-section at a single wavelength, the wavelength dependence of this cross-section, and the correct implementation and interpretation of statistical averages of cross-section properties over an ensemble of aggregate morphologies are generally quite complicated, and in fact are often misinterpreted in the literature. Despite this complexity, we have constructed a set of few-parameter formulae describing optical scattering from nanoparticle aggregates by judicious combination of experimental results with extensive, near-exact simulation using the T-matrix technique. These phenomenological results facilitate the practical use of nanoparticle aggregates for biological measurement and clinical therapeutic applications.

Paper Details

Date Published: 21 February 2008
PDF: 11 pages
Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690H (21 February 2008); doi: 10.1117/12.763869
Show Author Affiliations
Kort Travis, Univ. of Texas at Austin (United States)
Jesse Aaron, Univ. of Texas at Austin (United States)
Nathan Harrison, Univ. of Texas at Austin (United States)
Konstantin Sokolov, Univ. of Texas at Austin (United States)
Univ. of Texas M.D. Anderson Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 6869:
Plasmonics in Biology and Medicine V
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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