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Proceedings Paper

Gel phantom in selective laser phototherapy
Author(s): Yichao Chen; Christopher A. Bailey; Thomas M. Cowan; Feng Wu; Hong Liu; Rheal A. Towner; Wei R. Chen
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Paper Abstract

Tissue-simulating gel phantoms have been used in selective laser photothermal interaction. The gelatin phantom provides a uniform tissue-simulating medium for analyzing thermal performance under laser radiation. The gelatin phantom gel is used particularly in measurements of thermal reactions in laser thermology. The gelatin phantom is made from gelatin and Liposyn. A special gel sphere with Indocyanine Green (ICG) laser absorption enhancement dye is embedded in normal gel to simulate the dye-enhanced tumor in normal tissue. The concentration of ICG within the dye sphere is optimized using simulation for selective phototherapy. As a first attempt, the concentration of ICG and laser power density was optimized using a temperature ratio of target tissue versus surrounding tissue. The gel thermal performance is also monitored using MRI thermology imaging technology. The thermal imaging shows in vivo, 3D temperature mapping inside the gel. The study of thermal distribution using gel phantom provides information to guide the future selective laser photothermal thermal therapy.

Paper Details

Date Published: 21 February 2008
PDF: 9 pages
Proc. SPIE 6870, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue, 687008 (21 February 2008); doi: 10.1117/12.763831
Show Author Affiliations
Yichao Chen, Univ. of Central Oklahoma (United States)
Christopher A. Bailey, Univ. of Central Oklahoma (United States)
Thomas M. Cowan, Univ. of Central Oklahoma (United States)
Feng Wu, Chongqing Medical Univ. (China)
Hong Liu, Univ. of Oklahoma (United States)
Rheal A. Towner, Oklahoma Medical Research Foundation (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 6870:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue
Robert J. Nordstrom, Editor(s)

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