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Proceedings Paper

Development of a clinical Fourier-domain angle resolved low coherence interferometry system for in vivo measurements
Author(s): Neil G. Terry; Yizheng Zhu; William J. Brown; Adam Wax
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Paper Abstract

Improved methods for detecting dysplasia, or pre-cancerous growth are a current clinical need, particularly in the esophagus. The currently accepted method of random biopsy and histological analysis provides only a limited examination of tissue in question while being coupled with a long time delay for diagnosis. Optical scattering spectroscopy, in contrast, allows for inspection of the cellular structure and organization of tissue in vivo. Fourierdomain angle-resolved low-coherence interferometry (a/LCI) is a novel scattering spectroscopy technique that provides quantitative depth-resolved morphological measurements of the size and optical density of the examined cell nuclei, which are characteristic biomarkers of dysplasia. Previously, the clinical viability of the a/LCI system was demonstrated by analysis of ex vivo human esophageal tissue in Barrett's esophagus patients using a portable a/LCI system. We present an adaptation of the portable a/LCI instrument that can be used in the accessory channel of a gastroscope, allowing for in vivo measurements to be taken. Modifications to the previous generation system include the use of an improved imaging spectrometer allowing for subsecond acquisition times and the redesign of the delivery fiber and imaging optics in order to fit in the accessory channel of a gastroscope. Accurate sizing of polystyrene microspheres and other preliminary results are presented, demonstrating promise as a clinically viable tool.

Paper Details

Date Published: 1 March 2008
PDF: 9 pages
Proc. SPIE 6864, Biomedical Applications of Light Scattering II, 68640D (1 March 2008); doi: 10.1117/12.763782
Show Author Affiliations
Neil G. Terry, Duke Univ. (United States)
Yizheng Zhu, Duke Univ. (United States)
William J. Brown, Duke Univ. (United States)
Adam Wax, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 6864:
Biomedical Applications of Light Scattering II
Adam Wax; Vadim Backman, Editor(s)

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