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Proceedings Paper

An in vitro corneal model with a laser damage threshold at 2 μm that is similar to that in the rabbit
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Paper Abstract

Corneal organotypic cultures were generated as per existing methods, which included growth on polycarbonate inserts and air-lifting for one week. The corneal simulant cultures were exposed, with real-time IR imaging, to the 2-μm wavelength output of a thulium fiber laser with 4 mm beam diameter for 0.25 seconds in a thermally controlled environment and then assayed for damage. The in vitro threshold (ED50 value of 12.5 W/cm2) and peak temperature (74.5 °C) at threshold irradiance are compared with rabbit corneal data in the literature.

Paper Details

Date Published: 20 February 2008
PDF: 12 pages
Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 685415 (20 February 2008); doi: 10.1117/12.763543
Show Author Affiliations
Michael S. Foltz, Northrop Grumman (United States)
Michael L. Denton, Northrop Grumman (United States)
Kurt J. Schuster, Northrop Grumman (United States)
Larry E. Estlack, Conceptual Mindworks, Inc. (United States)
Semih S. Kumru, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 6854:
Optical Interactions with Tissue and Cells XIX
Steven L. Jacques; William P. Roach; Robert J. Thomas, Editor(s)

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