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Proceedings Paper

Polarized Raman spectroscopy: application to bone biomechanics
Author(s): Mekhala Raghavan; Michael D. Morris; Nadder D. Sahar; David H. Kohn
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Paper Abstract

Raman spectroscopic studies have shown that the properties of the organic matrix and the orientation of the mineral and matrix components of bone have a large influence on its properties. We employ polarized Raman microspectroscopy to monitor the changes in the orientation of mineral crystallites during tensile loading of bovine femora in the elastic regime. We load tissue in a custom-built dynamic mechanical tester that fits on the stage of a Raman microprobe and can accept hydrated tissue specimens. Parallel and perpendicular polarization components of the Raman spectra along the long axis of the diaphysis are obtained. We propose that the orientation and structure of mineral crystallites change on deformation of bone tissue by tensile loading.

Paper Details

Date Published: 8 February 2008
PDF: 8 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530W (8 February 2008); doi: 10.1117/12.763520
Show Author Affiliations
Mekhala Raghavan, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)
Nadder D. Sahar, Univ. of Michigan (United States)
David H. Kohn, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Wolfgang Petrich; Robert R. Alfano; Alvin Katz, Editor(s)

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