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Proceedings Paper

Effects of sciatic nerve stimulation on the propagation of cortical spreading depression
Author(s): Xiaoli Sun; Zhidong Yu; Shaoqun Zeng; Qingming Luo; Pengcheng Li
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Paper Abstract

Cortical spreading depression (CSD) is an important pathological model of migraine and is related to other neural disorders, such as cerebral ischemia and epilepsy. It has been reported that brain stimulation is a quite effective way to treat neural diseases. However, direct stimulation could cause harm to brain. If peripheral nerve stimulation could have the same treatment, it would be essential to investigate the mechanisms of peripheral nerve and the study of sciatic nerve stimulation would have profound clinical meaning. In this paper, we used optical intrinsic signal imaging (OISI) and extracellular electrophysiologic recording techniques to study the effects of sciatic nerve stimulation on the propagation of CSD. We found that: (1) continuous sciatic nerve stimulation on rats caused a decrease in light intensity on the whole cortex, which meant an increase in cerebral blood volume(CBV); (2) the spreading velocity of CSD declined from 3.63± 0.272 mm/min to 3.06±0.260 mm/min during sciatic nerve stimulation, compared with that without sciatic nerve stimulation. In summary, data suggests that sciatic nerve stimulation elicits a response of cortex and causes a slowdown in the propagation of CSD.

Paper Details

Date Published: 14 March 2008
PDF: 7 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630U (14 March 2008); doi: 10.1117/12.763372
Show Author Affiliations
Xiaoli Sun, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Zhidong Yu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Pengcheng Li, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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