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Proceedings Paper

Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors
Author(s): Anil Shetty; Amer Najjar; Andrew M. Elliott; Adam Springer; R. Jason Stafford; Ken Diller; Juri Gelovani; John D. Hazle
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Paper Abstract

Minimally invasive thermal therapy is gaining ground as a new treatment modality of prostate tumors. However, further understanding of molecular events like HSP70 expression is required for treatment planning and coordination with chemotherapy and radiation. Metastatic prostate tumor (PC3 MM2) cells, transduced with reporter genes, were utilized to study the expression of HSP70 induced by normal and nanoshell-mediated heating. A correlation was noted between HSP70 expression, cellular viability and heating temperatures. This imaging paradigm can be developed into a PET-MR thermal treatment regimen, which would include dosimetry planning, real time temperature monitoring and post treatment assessment of tumor response at a cellular level.

Paper Details

Date Published: 8 February 2008
PDF: 9 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420T (8 February 2008); doi: 10.1117/12.763361
Show Author Affiliations
Anil Shetty, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Amer Najjar, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Andrew M. Elliott, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Adam Springer, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
R. Jason Stafford, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Ken Diller, The Univ. of Texas at Austin (United States)
Juri Gelovani, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
John D. Hazle, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory; Guillermo J. Tearney; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Brian Jet-Fei Wong; Justus F. R. Ilgner; Henry Hirschberg; Steen J. Madsen, Editor(s)

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