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Proceedings Paper

Hemodynamic and electrophysiological responses to functional activation accessed by multi-wavelength optical imaging and electrophysiological recording system
Author(s): Nengyun Feng; Yuan Liu; Wenjia Wang; Qingming Luo; Pengcheng Li
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Paper Abstract

A compact and convenient system is designed and realized for high-resolution simultaneous imaging hemodynamic parameters and recording electrophysiological signals in the brain by the combination of multi-wavelength optical imaging and electrophysiological recording system. Multi-wavelength optical imaging system uses an integration of light-emitting diode (LED which has three wavelengths) and laser diode (LD) as imaging illuminants to combine the laser speckle imaging and optical intrinsic signal imaging. Electrophysiological recording system is based on the virtual instrument technology. The spatial and temporal changes in oxy-hemoglobin, deoxy-hemoglobin, total hemoglobin concentration, cerebral blood flow, and the cerebral metabolic rate of oxygen in response to the brain activities are monitored by the multi-wavelength optical imaging system. Meanwhile the electrophysiological recording system can simultaneously collect the extra-cellular electrophysiological signals. The combination system provides the capability to simultaneously investigate hemodynamic parameters and electrophysiological signals, which may lead to a better understanding of the coupling between neuronal activation and vascular responses.

Paper Details

Date Published: 14 March 2008
PDF: 6 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630B (14 March 2008); doi: 10.1117/12.763347
Show Author Affiliations
Nengyun Feng, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Yuan Liu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Wenjia Wang, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Pengcheng Li, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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