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Proceedings Paper

Role of superoxide dismutase in the photochemical response of cultured RPE cells to laser exposure at 413 nm
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Paper Abstract

Thresholds for photochemical damage were performed in RPE cell lines (artificially pigmented) taken from either human (hTERT-RPE1), wild type (wt) mouse, or transgenic mice deficient (+/-) in either superoxide dismutase 1 (SOD1) or SOD2. The four cell lines were characterized by immunohistochemical and immunoblot analyses to determine relative abundance of the SOD proteins. There was no difference in sensitivity between the human, murine wt and murine SOD1-deficient cells, whereas there was a dramatic (2 fold) increase in threshold irradiance value for the murine SOD2-deficient cells. Possible explanations for the unexpected result are provided.

Paper Details

Date Published: 25 February 2008
PDF: 8 pages
Proc. SPIE 6844, Ophthalmic Technologies XVIII, 68441O (25 February 2008); doi: 10.1117/12.763340
Show Author Affiliations
Michael L. Denton, Northrop Grumman (United States)
Michael S. Foltz, Northrop Grumman (United States)
Kurt J. Schuster, Northrop Grumman (United States)
Larry E. Estlack, Conceptual MindWorks, Inc. (United States)
Robert J. Thomas, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 6844:
Ophthalmic Technologies XVIII
Bruce E. Stuck; Michael Belkin; Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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