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Proceedings Paper

Fluorescence molecular-tomography reconstruction with a priori anatomical information
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Paper Abstract

In this study, we combine a generalized Tikhonov regularization method with a priori anatomical information to reconstruct the concentration of fluorophores in mouse with Chronic Obstructive Pulmonary disease (COPD) from in vivo optical and Magnetic Resonance (MR) measurements. Generalized Tikhonov regularization incorporates a penalty term in the optimization formulation of the fluorescence molecular tomography (FMT) inverse problem. Our design involves two penalty terms to make use of a priori anatomical structural information from segmented MR images. The choice of the penalty terms guide the fluorophores in reconstructed image concentrates in the region where it is supposed to be and assure smooth flourophore distribution within tissue of same type and enhances the discontinuities between different tissue types. We compare our results with traditional Tikhanov regularization techniques in extensive simulations and demonstrate the performance our approach in vivo mouse data. The results show that the increased fluorophore concentration in the mouse lungs is consistent with an increased inflammatory response expected from the corresponding animal disease model.

Paper Details

Date Published: 13 February 2008
PDF: 11 pages
Proc. SPIE 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes, 68680O (13 February 2008); doi: 10.1117/12.763269
Show Author Affiliations
Lu Zhou, Rensselaer Polytechnic Institute (United States)
Birsen Yazici, Rensselaer Polytechnic Institute (United States)
Vasilis Ntziachristos, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 6868:
Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes
Alexander P. Savitsky; Robert E. Campbell; Robert M. Hoffman, Editor(s)

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