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Proceedings Paper

Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors
Author(s): Anil Shetty; Andrew M. Elliott; Jon A. Schwartz; James Wang; Emilio Esparza-Coss; Sherry Klumpp; Brian Taylor; John D. Hazle; R. Jason Stafford
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Paper Abstract

This study investigates the potential of using gold nanoshells to mediate a thermally induced modulation of tumor vasculature in experimental prostate tumors. We demonstrate that after passive extravasation and retention of the circulating nanoshells from the tumor vasculature into the tumor interstitium, the enhanced nanoshells absorption of near-infrared irradiation over normal vasculature, can be used to increase tumor perfusion or shut it down at powers which result in no observable affects on tissue without nanoshells. Temperature rise was monitored in real time using magnetic resonance temperature imaging and registered with perfusion changes as extrapolated from MR dynamic contrast enhanced (DCE) imaging results before and after each treatment. Results indicate that nanoshell mediated heating can be used to improve perfusion and subsequently enhance drug delivery and radiation effects, or be used to shut down perfusion to assist in thermal ablative therapy delivery.

Paper Details

Date Published: 8 February 2008
PDF: 9 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420S (8 February 2008); doi: 10.1117/12.763160
Show Author Affiliations
Anil Shetty, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Andrew M. Elliott, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jon A. Schwartz, Nanospectra Biosciences, Inc. (United States)
James Wang, Nanospectra Biosciences, Inc. (United States)
Emilio Esparza-Coss, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Sherry Klumpp, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Brian Taylor, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
John D. Hazle, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
R. Jason Stafford, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory; Guillermo J. Tearney; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Brian Jet-Fei Wong; Justus F. R. Ilgner; Henry Hirschberg; Steen J. Madsen, Editor(s)

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