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Proceedings Paper

Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions
Author(s): Hui-Hsin Lu; Chii-Wann Lin; Tzu-Chien Hsiao; Chih-Kung Lee; Su-Ming Hsu
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Paper Abstract

We employed atomic force microscopy (AFM) with bias control to fabricate oxided nanopatterns on silicon surface with feature size down to 50nm. The relationship of silicon dioxide nanopatterns against humidity was studied and then the optimal parameter was used to make oxide nanoarry for interaction of biotin and streptavidin. The scanning function of AFM was utilized to verify the different height of biomolecules. According to our experimental results, using nano biochip of silicon dioxide can decrease the monitoring scale to nanometer and can be the nano-platform for monitoring the behavior of biomolecular interaction. We anticipate mimicking the correlation of single molecular behavior and an array of biomolecular behavior to understand the coincidence of them.

Paper Details

Date Published: 22 February 2008
PDF: 8 pages
Proc. SPIE 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, 68650D (22 February 2008); doi: 10.1117/12.762919
Show Author Affiliations
Hui-Hsin Lu, National Taiwan Univ. (Taiwan)
Chii-Wann Lin, National Taiwan Univ. (Taiwan)
Tzu-Chien Hsiao, National Chiao Tung Univ. (Taiwan)
Chih-Kung Lee, National Taiwan Univ. (Taiwan)
Su-Ming Hsu, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 6865:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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