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Proceedings Paper

Automatic retinal blood flow calculation using spectral domain optical coherence tomography
Author(s): Hassan Wehbe; Marco Ruggeri; Shuliang Jiao; Giovanni Gregori; Carmen A. Puliafito
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Paper Abstract

Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed of blood flow is a function of the Doppler angle, which needs to be determined in order to calculate the absolute velocity of the blood flow inside a vessel. We developed a technique that can extract the Doppler angle from the 3D data measured with spectral-domain OCT, which needs to extract the lateral and depth coordinates of a vessel in each measured ODT and OCT image. The lateral coordinates and the diameter of a blood vessel were first extracted in each OCT structural image by using the technique of blood vessel shadowgram, a technique first developed by us for enhancing the retinal blood vessel contrast in the en face view of the 3D OCT. The depth coordinate of a vessel was then determined by using a circular averaging filter moving in the depth direction along the axis passing through the vessel center in the ODT image. The Doppler angle was then calculated from the extracted coordinates of the blood vessel. The technique was applied in blood flow measurements in retinal blood vessels, which has potential impact on the study and diagnosis of blinding diseases like glaucoma and diabetic retinopathy.

Paper Details

Date Published: 18 February 2008
PDF: 5 pages
Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 68470I (18 February 2008); doi: 10.1117/12.762404
Show Author Affiliations
Hassan Wehbe, Univ. of Miami Miller School of Medicine (United States)
Marco Ruggeri, Univ. of Miami Miller School of Medicine (United States)
Shuliang Jiao, Univ. of Miami Miller School of Medicine (United States)
Giovanni Gregori, Univ. of Miami Miller School of Medicine (United States)
Carmen A. Puliafito, Univ. of Miami Miller School of Medicine (United States)


Published in SPIE Proceedings Vol. 6847:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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