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Proceedings Paper

Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes
Author(s): Xinmai Yang; Sara Skrabalak; Erich Stein; Bin Wu; Xunbin Wei; Younan Xia; Lihong V. Wang
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Paper Abstract

Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages, with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross-sections, should be better suited for in vivo applications. In this study, we tested Au nanocages as a contrast agent for PAT. The result suggests that Au nanocages are promising contrast agents for our applications. We also present PAT results when novel, dye-containing nanoparticles are used as contrast agents.

Paper Details

Date Published: 28 February 2008
PDF: 10 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560I (28 February 2008); doi: 10.1117/12.762401
Show Author Affiliations
Xinmai Yang, Washington Univ. in St. Louis (United States)
Sara Skrabalak, Univ. of Washington (United States)
Erich Stein, Washington Univ. in St. Louis (United States)
Bin Wu, Phosphorex, Inc. (United States)
Xunbin Wei, Fudan Univ. (China)
Younan Xia, Washington Univ. in St. Louis (United States)
Univ. of Washington (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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