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Proceedings Paper

The difference of the PDT's effects between interstitial lighting and continuous lighting in low oxygen density
Author(s): Jiumin Yang; Yingxin Li; Tiegen Liu; Tao Xu
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Paper Abstract

Tumor oxygen depletion plays an important role in the process of Photodynamic Therapy (PDT). The paper focuses on the improvement of the lighting mode to carry out this cancer therapy more effectively in low oxygen content. The effect of interstitial lighting was compared with that of continuous lighting in different oxygen density measured with a homemade device in PDT. 90 mice were divided into 3 groups: the contrast group, the continuous lighting group and the interstitial lighting group. The initial oxygen content was measured with a homemade device before the treatment. To examine the different effects, both the interstitial lighting and the continuous lighting have the same fluent rates (30mW/cm2, 32.4J/ cm2). The continuous lighting lasted 18 minutes while the interstitial lighting lasted 36 minutes with 1 second's idle time and 1 second's effective time of each pulse. The result shows that the volume of tumor doubling duration in interstitial lighting group is longer in the condition of low initial oxygen content. Thus with low initial oxygen content, the interstitial lighting is more effective than the continuous lighting during PDT.

Paper Details

Date Published: 12 February 2008
PDF: 5 pages
Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 684510 (12 February 2008); doi: 10.1117/12.762375
Show Author Affiliations
Jiumin Yang, Tianjin Medical Univ. (China)
Tianjin Univ. (China)
Yingxin Li, Tianjin Medical Univ. (China)
Tiegen Liu, Tianjin Univ. (China)
Tao Xu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6845:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII
David Kessel, Editor(s)

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