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Proceedings Paper

The relationship of QD composition and conjugate to cellular uptake and toxicity
Author(s): Jay L. Nadeau; Samuel J. Clarke; Anil Kumar Suresh; Rafael A. Khatchadourian; Eve-Marie Dumas
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Paper Abstract

In this work, we demonstrate the application of quantum dots (QDs) to several biologically relevant applications. QDs are synthesized by biological and organometallic routes and the relative merits of these methods are identified. Our results indicate that QDs can be functionalized and specifically targeted to both mammalian and bacterial cells. In the case of mammalian cells, they can be targeted to an engineered sodium channel for the purpose of sensing. In both mammalian and bacterial cells, the interaction with bioconjugated QDs can lead to phototoxicity due to the generation of reactive oxygen species (ROS).

Paper Details

Date Published: 22 February 2008
PDF: 11 pages
Proc. SPIE 6866, Colloidal Quantum Dots for Biomedical Applications III, 68660J (22 February 2008); doi: 10.1117/12.762333
Show Author Affiliations
Jay L. Nadeau, McGill Univ. (Canada)
Samuel J. Clarke, McGill Univ. (Canada)
Anil Kumar Suresh, McGill Univ. (Canada)
Rafael A. Khatchadourian, McGill Univ. (Canada)
Eve-Marie Dumas, McGill Univ. (Canada)

Published in SPIE Proceedings Vol. 6866:
Colloidal Quantum Dots for Biomedical Applications III
Marek Osinski; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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