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Proceedings Paper

Inactivation of viruses with a femtosecond laser via impulsive stimulated Raman scattering
Author(s): K. T. Tsen; Shaw-Wei D. Tsen; Chih-Long Chang; Chien-Fu Hung; T.-C. Wu; B. Ramakrishna; K. Mossman; Juliann G. Kiang
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Paper Abstract

The inactivation of viruses such as M13 bateriophages subject to excitations by a very low power visible femtosecond laser has been studied. Our experimental results show that for a visible femtosecond laser having λ = 425nm and a pulse width of 100 fs, the M13 bacteriophages are inactivated when the laser power density is greater than or equal to 50 MW / cm2. The functionality of M13 bacteriophages has been shown to be critically dependent on the pulse width as well as power density of the excitation laser. Our work demonstrates that by using a very low power visible femtosecond laser, it is plausible to inactivate viruses such as the M13 bacteriophages through Impulsive Stimulated Raman Scattering (ISRS) process. These experimental findings lay down the foundation for a novel new avenue of selectively inactivating microorganisms while leaving the sensitive materials unharmed by manipulating and controlling with femtosecond laser systems.

Paper Details

Date Published: 20 February 2008
PDF: 10 pages
Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 68540N (20 February 2008); doi: 10.1117/12.762324
Show Author Affiliations
K. T. Tsen, Arizona State Univ. (United States)
Shaw-Wei D. Tsen, Johns Hopkins Univ. School of Medicine (United States)
Chih-Long Chang, Johns Hopkins Univ. School of Medicine (United States)
Chien-Fu Hung, Johns Hopkins Univ. School of Medicine (United States)
T.-C. Wu, Johns Hopkins Univ. School of Medicine (United States)
B. Ramakrishna, Arizona State Univ. (United States)
K. Mossman, Arizona State Univ. (United States)
Juliann G. Kiang, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 6854:
Optical Interactions with Tissue and Cells XIX
Steven L. Jacques; William P. Roach; Robert J. Thomas, Editor(s)

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