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Proceedings Paper

Near-infrared autofluorescence spectroscopy for in vivo diagnosis of cervical precancer
Author(s): Jianhua Mo; Wei Zheng; Jeffrey Low; Joseph Ng; A. Ilancheran; Zhiwei Huang
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Paper Abstract

The purpose of this study is to explore the feasibility of utilizing near-infrared (NIR) autofluorescence spectroscopy for in vivo diagnosis of precancer (i.e., dysplasia) in the cervix. A rapid NIR spectroscopy system in combination with a fiber-optic probe was developed for the in vivo NIR fluorescence measurements under the 785 nm laser excitation. Multivariate statistical techniques including principal component analysis (PCA) and linear discriminant analysis (LDA) were employed to develop the diagnostic algorithms for spectra classification. Classification result obtained from the PCA-LDA model based on tissue NIR autofluorescence data yielded a diagnostic sensitivity of 84.8% and specificity of 85.1% for discrimination of precancer from normal cervical sites. The results demonstrate that NIR autofluorescence technique has the capacity for the noninvasive, in vivo diagnosis of precancer in the cervix.

Paper Details

Date Published: 8 February 2008
PDF: 5 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 685317 (8 February 2008); doi: 10.1117/12.762181
Show Author Affiliations
Jianhua Mo, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Jeffrey Low, National Univ. Hospital (Singapore)
National Univ. of Singapore (Singapore)
Joseph Ng, National Univ. Hospital (Singapore)
National Univ. of Singapore (Singapore)
A. Ilancheran, National Univ. Hospital (Singapore)
National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Wolfgang Petrich; Robert R. Alfano; Alvin Katz, Editor(s)

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