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Proceedings Paper

Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements
Author(s): Franck Jaillon; Wei Zheng; Zhiwei Huang
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Paper Abstract

The association of a beveled collection fiber with a half ball lens is here simulated in order to illustrate the enhancement brought by this simple method in depth resolved measurements, the latter being of major importance in the study of epithelial tissues. Indeed, in order to follow the carcinogenesis stage by a non invasive technique such as fluorescence or Raman spectroscopy, it is valuable to be able to discriminate the depth origin of the detected signal. The proposed probe design consists in a beveled collection fiber positioned on the center of the half ball lens flat surface with an off-axis excitation flat fiber. Depending on the bevel angle of the collection fiber, discrimination between the epithelial and the stromal layer can be realized.

Paper Details

Date Published: 12 February 2008
PDF: 5 pages
Proc. SPIE 6849, Design and Quality for Biomedical Technologies, 68490E (12 February 2008); doi: 10.1117/12.762177
Show Author Affiliations
Franck Jaillon, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 6849:
Design and Quality for Biomedical Technologies
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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