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Proceedings Paper

Using skin impedance to improve prediction accuracy of continuous glucose monitoring system
Author(s): Haixia Yu; Jin Liu; Ting Shi; Dachao Li; Zhenhui Du; Kexin Xu
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Paper Abstract

The continuous blood glucose monitoring system using interstitial fluid (ISF) extracted by ultrasound and vacuum is proposed in this paper. The skin impedance measurement is introduced into the system to monitor the skin permeability variation. Low-frequency ultrasound is applied on skin surface to enhance the skin permeability by disrupting the lipid bilayers of the stratum corneum (SC), and then ISF is extracted out of skin continuously by vacuum. The extracted ISF is diluted and the concentration of glucose in it is detected by a biosensor and used to predict the blood glucose concentration. The skin permeability is variable during the extraction, and its variation affects the prediction accuracy. The skin impedance is an excellent indicator of skin permeability in that the lipid bilayers of the SC, which offer electrical resistance to the skin, retard transdermal transport of molecules. So the skin impedance measured during the extraction is transformed to skin conductivity to estimate correlation coefficient between skin conductivity and permeability. Skin conductivity correlates well with skin permeability. The method and experiment system mentioned above may be significative for improving the prediction accuracy of continuous blood glucose monitoring system.

Paper Details

Date Published: 22 February 2008
PDF: 8 pages
Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 68630S (22 February 2008); doi: 10.1117/12.762154
Show Author Affiliations
Haixia Yu, Tianjin Univ. (China)
Jin Liu, Tianjin Univ. (China)
Ting Shi, Tianjin Univ. (China)
Dachao Li, Tianjin Univ. (China)
Zhenhui Du, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 6863:
Optical Diagnostics and Sensing VIII
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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