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Proceedings Paper

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers
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Paper Abstract

We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.

Paper Details

Date Published: 5 March 2008
PDF: 7 pages
Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 684708 (5 March 2008); doi: 10.1117/12.761850
Show Author Affiliations
Desmond C. Adler, Massachusetts Institute of Technology (United States)
Yu Chen, Massachusetts Institute of Technology (United States)
Robert Huber, Massachusetts Institute of Technology (United States)
Ludwig-Maximilians-Univ. München (Germany)
Joseph Schmitt, LightLab Imaging, Inc. (United States)
James Connolly, Beth Israel Deaconess Medical Ctr. (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 6847:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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