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Proceedings Paper

A modified commercial ultrasound scanner used for in vivo photoacoustic imaging of nude mice injected with non-targeted contrast agents
Author(s): Ladislav Jankovic; Khalid Shahzad; Yao Wang; Michael Burcher; Frank-Detlef Scholle; Peter Hauff; Sabine Mofina; Mihaela Skobe
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Paper Abstract

Photoacoustic (PA) experiments were performed using a modified commercial ultrasound scanner equipped with an array transducer and a Nd:YAG pumped OPO laser. The contrast agent SIDAG (Bayer Schering Pharma AG, Germany), used to enhance the optical absorption, demonstrated an expected pharmacokinetic behavior of the dye in the tumor and in the bladder of the nude mice. A typical behavior in the tumor consisted of an initial linear increase in PA signal followed by an exponential decay. PA signal approached the pre-injection level after about one hour following the dye injection, which was consistent with the behavior for such contrast agents when used in other imaging modalities, such as fluorescence imaging. The in-vivo spectral PA data from the mouse bladder, conducted 1.5 hours after the dye injection, clearly demonstrated presence of the dye. The multi-spectral PA data was obtained at 760nm, 784nm and 850nm laser excitations. The PA intensities obtained at these three wavelengths accurately matched the dye absorption spectrum. In addition, in the kidney, a clearance organ for this contrast agent, both in-vivo and ex-vivo results demonstrated a significant increase (~ 40%) in the ratio of PA signal at 760nm (the peak of the dye absorption) relative to the signal at 850nm (<1% absorption), indicating significant amounts of the dye in this organ. Our initial results confirm the desired photoacoustic properties of the contrast agent, indicating its great potential to be used for imaging with a commercial array-based ultrasound scanner.

Paper Details

Date Published: 4 March 2008
PDF: 9 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560O (4 March 2008); doi: 10.1117/12.761828
Show Author Affiliations
Ladislav Jankovic, Philips Research NA (United States)
Khalid Shahzad, Philips Research NA (United States)
Yao Wang, Philips Research NA (United States)
Michael Burcher, Philips Research NA (United States)
Frank-Detlef Scholle, Bayer Schering Pharma AG (Germany)
Peter Hauff, Bayer Schering Pharma AG (Germany)
Sabine Mofina, Mount Sinai School of Medicine (United States)
Mihaela Skobe, Mount Sinai School of Medicine (United States)

Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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