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Proceedings Paper

Laser-optical methods of detection and elimination of local tissue hypoxia: new approaches in predicting and preventing the risk of solid tumor formation
Author(s): M. M. Asimov; R. M. Asimov; A. N. Rubinov
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Paper Abstract

Hypoxia - the deficit of oxygen - in solid tumor is the major problem that limits the efficiency of the radiotherapy, chemotherapy and photodynamic therapy. Hypoxia in cancer tissues caused by the fast growth of cancer cells that leads to disordering the process of angiogenesis. Hypoxia becomes severe in the method of photodynamic therapy of solid tumors because tumor destruction based on photochemical generation of singlet oxygen (1O2) and its reaction with cellular substrates. Extra oxygen extraction from blood is necessary to avoid rapid reduction in time the efficiency of the method of photodynamic therapy. Prevention of tumor tissue hypoxia and improvement of the oxygenation of solid tumor bulk remains an actual problem in modern Cancerology. In this paper new approach to solving of the problem the local chronic hypoxia based on technology of laser-induced tissue oxygenation is proposed. Noninvasive laser-optical diagnostic method of the local tissue hypoxia is also developed. The original optical model of laser - tissue interaction and algorithm of mathematical calculation of optical field inside tissue is developed. It is shown that by analyzing surface distribution of the intensity of incident and transmitted light it is possible to restore the image of blood vascular vessels. The visualization of superficial skin blood vessels is experimentally demonstrated. Laser-induced tissue oxygenation in combination with the visualization the local net of tissue blood vessels may become helpful instrument in photomedicine both in diagnosis earlier risk and prevention and increasing the efficiency of therapeutic response of solid tumors.

Paper Details

Date Published:
PDF: 8 pages
Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 68540R; doi: 10.1117/12.761635
Show Author Affiliations
M. M. Asimov, Institute of Physics (Belarus)
R. M. Asimov, Applied Systems Ltd. (Belarus)
A. N. Rubinov, Institute of Physics (Belarus)

Published in SPIE Proceedings Vol. 6854:
Optical Interactions with Tissue and Cells XIX
Steven L. Jacques; William P. Roach; Robert J. Thomas, Editor(s)

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