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Proceedings Paper

Photoacoustic imaging of tumor angiogenesis
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Paper Abstract

Photoacoustic imaging is a hybrid imaging modality that is based on the detection of acoustic waves generated by absorption of pulsed light by tissue chromophores such as hemoglobin in blood. Serial photoacoustic imaging has been performed over a 10-day period after subcutaneous inoculation of pancreatic tumor cells in a rat. The images were obtained from ultrasound generated by absorption in hemoglobin of short laser pulses at a wavelength of 1064 nm. The ultrasound signals were measured in reflection mode using a double-ring photoacoustic detector. A correction algorithm has been developed to correct for scanning and movement artifacts during the measurements. Three-dimensional data visualize the development and quantify the extent of individual blood vessels around the growing tumor, blood concentration changes inside the tumor and growth in depth of the neovascularized region.

Paper Details

Date Published: 5 February 2008
PDF: 6 pages
Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685602 (5 February 2008); doi: 10.1117/12.761214
Show Author Affiliations
Roy G. M. Kolkman, Univ. of Twente (Netherlands)
Kiran K. Thumma, Univ. of Twente (Netherlands)
Gerbert A. ten Brinke, Univ. of Twente (Netherlands)
Ronald I. Siphanto, Univ. Medical Ctr. Rotterdam (Netherlands)
Han van Neck, Univ. Medical Ctr. Rotterdam (Netherlands)
Wiendelt Steenbergen, Univ. of Twente (Netherlands)
Ton G. van Leeuwen, Univ. of Twente (Netherlands)
Academic Medical Ctr., Univ. of Amsterdam (Netherlands)


Published in SPIE Proceedings Vol. 6856:
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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